Study and Strategy of Anti-tumor Metastasis Based on Extracellular Exosomes / 世界科学技术-中医药现代化

ABSTRACT

An "exosome" is a nano-grade biological membrane structure with a diameter of 40 nm-130 nm from cell endocytosis.Exosomes,which are enriched with a subset of proteins,nucleic acid and lipids,represent an important manner for the intercellular communication and exchanging of substances.Exosomes play a critical role at the pathological state such as tumor metastasis as well as in normal physiological state.Metastasis is the main characteristics of malignant tumors.It is the leading cause of tumor recurrence,treatment failure and death.This paper reviewed the current understanding of relationship between exosomes,tumor metastasis and their potential applications as antimetastasis strategy from biosynthesis inhibition,drug delivery system construction and metastasis related signal pathway blocking based on targeting exosomes,especially introduced the future prospects of exosome as drug vehicles for metastasis treatment.With further progress in research,this kind of strategy will be beneficial to anti-tumor metastasis treatment.