Study on the Relationship between Serum Omentin-1 Level and Degree of Kidney Injuryin Patient with Type 2 Diabetic Nephropathy / 现代检验医学杂志

ABSTRACT

Objective To explore the relationship between serum Omentin-1 level and degree of kidney in juryin patient with type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groupsDM (44 cases) and DN (56 cases) group,and by Mogenson,DN group were devided into DN1 (30 cases) and DN2 (26 cases).In addition 80 healthy subjects were selected as control group.HbA1c,BUN,Scr,β2-MG,HOMA-IR and serum Omentin-1 leves were detected by the standard method.Results There were obvious differences of HbA1c,BUN,Scr,β2-MG,HOMA-IR and Serum Omentin-1 levels among DN,DM and NC (F=6.078～16.231,all P＜0.05).Apart of HbA1c and HOMA-IR,others were no differences between DM group and NC group (t=1.421～2.637,all P＞0.05).There were significant differences of these indicators between DN and NC group (t=8.981～26.785,all P＜0.05).DN group was higher significantly than these in DM group (t=6.371～21.673,all P＜0.05),and HbA1c,BUN,Scr and β2-MG levels had no statistical difference between DN1 and DN2 group (t 0.981～1.389,all P＞0.05).HOMA-IR level in DN2 was higher than that in DN1 group,and serum Omentin 1 declined (t=68.451～76.814,all P＜0.01).There were negative correlation between HOMA IR and serum Omentin-1 leves (r=-0.405,P＜0.05).Conclusion Serum Omentin-1 was related to insulin resistance.Serum Omentin 1 in serum may be a role indicator for impairment of renal function for diagnosis of type 2 diabetic nephropathy.