Expression of CD133-2 during the Courses of Acute Leukemia and Its Clinical Significance / 现代检验医学杂志
Journal of Modern Laboratory Medicine
;
(4): 35-37, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-696202
ABSTRACT
Objective To explore the expression of CD133-2 during the treatment course of acute leukemia(AL) and its clinical significance.Methods Used flow cytometry with direct immunofluorescence staining to analyze CD133-2 of 67 acute leukemia patients with different treatment courese.Results The CD133-2 positive rate (52.4%)and expression rate (23.9%±21.5%) in AL were significantly higher than those in control (0,2.2% ±3.9%).The CD133-2 positive rates of cases for primary treatment group,CR group and recurrence group were 52.4 %,0 and 40.0 % respcctively,and expression rates were 23.9%±21.5%,5.0%±6.0% and 28.4%±25.6% respectively.There were significant difference in the positive rate and expression rate of CD133-2 among the three group (x2 =12.777,F=5.906,P<0.05).The CD133-2 positive rates and expression rates in primary treatment group and recurrence group were significantly higher than those in complete remission cases.CD133-2 positive rate of CD34 + group was obviously higher than that of CD34-group (40.5% vs 7.1%,x2=8.636,P<0.05),and the CR rate of CD133-2-/CD34-group was significantly higher than that of CD133-2+/CD34 +group (83.3% vs 33.3%,x2=6.078,P<0.05).Conclusion The expression of CD133-2 was correlated with CD34,and CD133/CD34 co-overexpression might be a bad prognostic factor of AL.CD133-2 can be used as one of the indicator of predicting recurrence and monitoring MRD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Modern Laboratory Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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