Clinical analysis of mumps meningoencephalitis in children without parotitis / 中华实用儿科临床杂志

ABSTRACT

Objective To explore the morbidity and clinical characteristics of mumps meningoencephalitis in children without parotitis.Methods Two hundred and twenty-three cerebrospinal fluid (CSF) specimens were collected from children who were diagnosed as viral encephalitis at Department of Pediatrics,the Second Affiliated Hospital of Shantou University Medical College from June 2010 to February 2016.Multiplex PCR was applied to detect the mumps virus,and other common viral,including measles virus,enterovirus,enterovirus 71 type,coxsackie virus A16 type,dengue virus,Japanese encephalitis virus,rubella virus,herpes simplex virus,human cytomegalovirus,Epstein-Barr virus,Chikungunya virus and Charon evagatus in mumps virus positive specimens were detected by PCR.The clinical data of patients with mumps virus infection were analyzed.Results In 223 CSF specimens,positive mumps virus were detected in 11 cases (4.9％),of whom,the mycobacterial,fungal,conventional CSF cultures and other common viral cause in CSF were negative.One case presented parotitis on the sixth day after admission.Of 11 cases with positive mumps virus,there were 10 cases without parotitis.The cardinal symptoms of mumps meningoencephalitis in children without parotitis were fever,headache,vomiting and seizures,and the CSF parameters,brain magnetic resonance imaging,electroencephalogram ofthe patients were all similar to other viral encephalitis,while the prognosis was good in children with mumps meningoencephalitis without parotitis,but the CSF return to normal needed a long time,the longest time up to 4 weeks.Conclusion Mumps meningoencephalitis may occur in children without parotitis,and the most common symptom are fever,headache,vomiting and seizures.