Recent advances in the relationship between orthostatic intolerance and regulatory mechanism of calcium me-tabolism in children / 中华实用儿科临床杂志

ABSTRACT

Orthostatic intolerance(OI)is the most common type of neurally mediated syncope in children. At present,the pathogenesis of OI in children is not yet clear,but in recent years,studies have found that the deficiency or lack of calcium,vitamin D are correlated with OI. Calcium ion is a second messenger that participates in the process of intercelluar communication. It has a wide range of biological effects in many tissues and cells in the body. Calcium ion plays an important role in children′s OI and other cardiovascular diseases. Calcium,vitamin D deficiency or abnormality of channel protein kinase may influence the occurrence and outcome of OI by influencing the activation of cardiac mus-cle cells,vascular endothelial cells and platelet. In this paper,the relationship between calcium,vitamin D and OI and its possible mechanism of action are discussed.