Drug-related acute kidney injury in children / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 321-325, 2018.
Article
em Zh
| WPRIM
| ID: wpr-696388
Biblioteca responsável:
WPRO
ABSTRACT
Drug-related acute kidney injury(AKI)is a common problem in clinical medicine.It is more prone to occur in children,especially in children with severe infection,low circulating blood volume,congestive heart failure,diabetes and chronic kidney disease clinically.Mechanisms include altered intra-glomerular haemodynamics, oxidative damage,hypersensitivity reactions,renal obstruction,tubular inflammatory changes,interstitial nephritis,rhab-domyolysis,thrombotic microvascular disease and metabolic disorders. Therefore,the early detection of adverse drug reactions to prevent its progression to end-stage renal disease is important.Despite many efforts to improve the early assessment of AKI in patients,effective markers are still lacking.Preventive measures requires knowledge of mecha-nisms of drug-induced AKI,improve the prognosis by correcting risk factors,assessing baseline renal function before initiation of therapy,adjusting the drug dosage and avoiding use of nephrotoxic drug combinations.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
/
Screening_studies
Idioma:
Zh
Revista:
Chinese Journal of Applied Clinical Pediatrics
Ano de publicação:
2018
Tipo de documento:
Article