Research progress on signal pathways relevant to Hirschsprung's disease / 中华实用儿科临床杂志

ABSTRACT

Hirschsprung's disease(HSCR)is a kind of complex digestive system disease with structural abnor-malities,implicated a genetic,polygenic,multifactorial disease. Etiology and pathogenesis of HSCR are not clear,now re-search shows there is complex,multiple and abnormal signal transduction with development of HSCR. The variable phe-notypic of HSCR may be the result of some gene mutation interfering with ganglion cell migration in signal pathway. Re-cently study has found that there are several signal transduction pathways strongly relevant to HSCR. Now,the research progress in primarily signal pathways relevant to HSCR were reviewed.