Treatment of phosphate retention: The earlier the better?
Kidney Research and Clinical Practice
;
: 3-8, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-69685
ABSTRACT
Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20th century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack in disputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Cálcio
/
Insuficiência Renal Crônica
/
Hiperfosfatemia
/
Homeostase
/
Hipercalcemia
/
Hiperparatireoidismo Secundário
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2014
Tipo de documento:
Artigo
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