Magnetic resonance spectroscopy study of the left posterior cingulate cortex in type 2 diabetic encephalopathy patients / 实用放射学杂志

ABSTRACT

Objective To analyze the changes of metabolites in the left posterior cingulate cortex (PCC)in patients with type 2 diabetes mellitus (T2DM),diabetic encephalopathy(DE)and healthy control(HC),to discuss the pathogenesis and to provide the biological information for the early diagnosis of DE.Methods 46 patients with clinical diagnosis of T2DM and 26 matched HC were received single-voxel MRS on the left PCC using Siemens Verio 3.0T MR scanner.Participants were divided into two groups based on MoCA scoring criteria and diabetic retinopathy,including DM group (n=31)and DE group (n=15).All T2DM patients were received fasting blood glucose,glycated hemoglobin (HbAlc)and other clinical labortory tests before MR scans.SPSS 21.0 software package was used for statistical analysis.Results (1)Ins and Ins/Cr were increased gradually in DE compared with HC and DM groups(P＜0.05).(2) NAA/Ins ratio in DE group was significant lower than that in DM and HC group,but no significant difference was observed between DM and DE groups(P＞0.05).No significant differences exsited in NAA/Cr among these three groups(P＞0.05).Conclusion MRS can be more sensitive to detect DE patients on the left PCC-related metabolic abnormalities and help DE with early screening and preliminary clinical diagnosis.The increase Ins/Cr in the left PCC area is more sensitive to the brain injury of T2DM and can refelect the progress degree.It is necessary to expand the sample size to verify its diagnostic efficacy and early warning of the brain injury.