Preliminary study of CT targeted contrast agent of gold nanoparticles-recombinant high-density lipoprotein in animal model / 实用放射学杂志

ABSTRACT

Objective To investigate CT targeted contrast agent of gold nanoparticles-recombinant high-density lipoprotein (Au-rHDL)in analyzing the relationship between molecular imaging and pathology for macrophages in atherosclerotic plaques in living animals. Methods Au-rHDL targeted contrast agents and atherosclerotic animal models were obtained.Targeted images for macrophages in living animal models were matched with the corresponding pathological sections,and the correlation and consistency between macrophages distribution and plaque burden were analyzed.Results ① Au-rHDL targeted contrast agent had biological activity,which could specifically combine with macrophages in atherosclerotic plaques;② There was no statistical difference between the location of macrophages and the results of plaque burden (P=0.863,0.726),and the results of two methods had high correlation (r=0.897,0.736)and consistency (ICC=0.885,0.763).Conclusion The molecular imaging technology basing on CT targeted contrast agent of Au-rHDL can be used for analyzing the identification and localization of macrophages in atherosclerotic plaque,and providing a theoretical basis for early warning and vulnerability risk prediction of atherosclerotic plaques.