Abnormal expression of miR-132 in peripheral blood mononuclear cells and plasma of the patients with oral lichen planus and its clinical significance / 实用口腔医学杂志

ABSTRACT

Objective:To investigate the expression of miR-132 in peripheral blood mononuclear ceils(PBMCs) and plasma of patients with oral lichen planus (OLP) and the relationship of miR-132 with clinical forms of OLP.Methods:40 OLP patients (24 nonerosive OLP,16 erosive OLP) and 40 healthy controls were included.The relative expression of miR132 in peripheral blood mononuclear cells (PBMCs) and plasma was examined by quantitative real-time PC R.Results:The expression of miR-132 in both PBMCs and plasma of OLP patients was significantly higher than those in healthy controls(P ＜ 0.01).miR-132 expression of PBMCs and plasma in erosive OLP group was significantly higher than that in non-erosive OLP group and healthy control(P ＜ 0.01).However,the expression of miR-132 in PBMCs and plasma showed no significant difference between non-erosive OLP group and healthy control (P ＞0.05).Conclusion:miR-132 might be involved in the abnormal immune response of OLP patients,and miR-132 can be utilized as an assistant biomarker for the evaluation of the severity of OLP.