Association between follicular output rate and clinical outcome in patients with polycystic ovarian syndrome / 实用医学杂志

ABSTRACT

Objective To find the association between follicular output rate and clinical outcome in patients with polycystic ovarian syndrome (PCOS).Methods A total of 285 female patients with PCOS who were undergoing in vitro fertilization-embryo transfer (IVF-ET) for the first time were included in the study and were divided into three groups according to follicular output rate (FORT) values.The general information,the parameters of the controlled ovarian hyperstimulation,and clinical outcomes were compared.Results The concentration of serum E2 on the day of HCG,preovulatory follicle count (PFC),the number of retrieved oocytes,good-quality embryo rates,clinical pregnancy rate decreased sequently in groups with high,mediate and low FORT value.The incidence of moderate and severe ovarian hyper-stimulation syndrome (OHSS) in the group with mediate FORT value was significantly lower than that of groups with high and low FORT value.The incidence of severe OHSS in 3 groups with high,mediate and low FORT value was 20.6％,9％ and 17.8％ respectively and the difference was statistically significant (P =0.037).Conclusions The value of FORT may predict the clinical outcome of IVF/ ICSI-ET in patients with PCOS.Effort should be made to prevent OHSS in PCOS patients with high or low FORT value in their controlled ovarian hyperstimulation cycles.