The relationship between the expression of plasma miRNA-195 in patients with severe coronary artery ste-nosis and its coronary collateral circulation / 实用医学杂志
The Journal of Practical Medicine
;
(24): 265-268, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-697599
ABSTRACT
Objective To investigate the relationship between the expression of plasma miRNA-195 in pa-tients with severe coronary artery stenosis and its coronary collateral circulation. Methods One hundred and nine-ty patients with selective coronary angiography in our hospital from March 2000 to May 2017 were enrolled,who were divided into poor collateral circulation group(n = 90)and good collateral circulation group(100 cases)ac-cording to the Rentrop classification.Plasma miRNA-195 and VEGF levels were compared between the two groups. The relationship between plasma miRNA-195 and VEGF was analyzed,and also the relationship between plasma miRNA-195 and Gensini points.Results(1)Plasma miRNA-195 and VEGF levels in good collateral circulation group were significantly higher than those in poor collateral circulation group(P<0.05).(2)There was a positive correlation between plasma miRNA-195 and VEGF in patients with coronary heart disease(r=0.628,P=0.022). (3)There was a positive correlation between plasma miRNA-195 and Gensini score in patients with coronary heart disease(r = 0.765,P = 0.013). Conclusion MiRNA-195 may be involved in the production of neovasculariza-tion by regulating VEGF in the formation of collateral circulation in patients with severe coronary artery stenosis, which can be used as a biomarker for predicting the formation of collateral circulation for clinical reference.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
The Journal of Practical Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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