Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China
The Korean Journal of Parasitology
;
: 379-384, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-69769
ABSTRACT
Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in the surveillance of the resistance. In this study, we investigated the prevalence of mutations in pvmdr1, pvcrt-o, pvdhfr, and pvdhps genes in temperate-zone P. vivax parasites from central China. A total of 26 isolates were selected, including 8 which were previously shown to have a lower susceptibility to chloroquine in vitro. For pvmdr1, pvcrt-o, and pvdhps genes, no resistance-conferring mutations were discovered. However, a highly prevalent (69.2%), single-point mutation (S117N) was found in pvdhfr gene. In addition, tandem repeat polymorphisms existed in pvdhfr and pvdhps genes, which warranted further studies in relation to the parasite resistance to antifolate drugs. The study further suggests that P. vivax populations in central China may still be relatively susceptible to chloroquine and sulfadoxine-pyrimethamine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasmodium vivax
/
Resistência a Medicamentos
/
Proteínas de Protozoários
/
China
/
Cloroquina
/
Prevalência
/
DNA de Protozoário
/
Malária Vivax
/
Análise de Sequência de DNA
/
Mutação Puntual
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2012
Tipo de documento:
Artigo
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