Effects of different hemodialysis methods on vitamin K2 and abdominal aortic calcification / 实用医学杂志

ABSTRACT

Objective To compare the effects of different hemodialysis methods on vitamin K2and abdomi-nal aortic calcification.Methods From January 2016 to June 2017,collect 60 maintenance hemodialysis(MHD) patients in the First Affiliated Hospital of Shihezi University,including low flux hemodialysis(HD)patients with 30 cases and high flux hemodialysis(HFHD)patients with 30 cases.Selecting 30 cases as healthy group and con-trol group with similar sex and age.Blood biochemical detection of serum calcium,phosphorus,magnesium,albu-min,parathyroid hormone and other indicators were deternmined.Detecting the abdominal aortic calcification score calculation with abdominal lateral X-ray.Detecting serum vitamin K2levels in the three groups with ELISA.Further analyzing the correlation between vitamin K2levels and abdominal aortic calcium integration. Results Firstly, compared with the control group,vitamin K2levels in group HD and group HFHD were decreased(P<0.05).Vi-tamin K2levels in group HD were lower than those in group HFHD(P<0.05).Secondly,the score of abdominal aorta calcification in group HD was higher than that in group HFHD(P<0.05).Thirdly,levels of vitamin K2and abdominal aortic calcification score were negatively correlated(r =-0.319,P < 0.05),and 25(OH)VD3,calci-um,phosphorus,magnesium,calcium and phosphorus product,parathyroid hormone had no correlation(P >0.05). Conclusion In MHD patients,the level of vitamin K2in HFHD group is higher than that in HD group, the abdominal aortic calcification score is lower than that of HD group,and vitamin K2can delay the process of vas-cular calcification.