Application of BIS-guided TCI with propofol and remifentanil for interventional embolization therapy of cerebral aneurysm / 实用医学杂志

ABSTRACT

Objective To investigate the value of BIS-guided TCI with propofol and remifentanil for inter-ventional embolization therapy of cerebral aneurysm. Methods Sixty-eight patients of both sexes undergoing elec-tive cerebral aneurysm embolization were randomly divided into two groupsGroup A(TCl with propofol and remi-fentanil),Group B(BIS-guided TCl with propofol and remifentanil). Group A was adjusted the concentration of propofol depending on clinical experience and hemodynamic changes,while group B adjusted the concentration of propofol depending on BIS which was maintained between 45 to 60. The total anesthesia time and dosage of propo-fol,duration of recovery and extubation,the incidence of restlessness and hypoxemia at extubion were recorded. In-traoperative awareness and incidence of nausea and vomiting were also recorded as postoperative visiting after 24 hours. Results In comparison two groups,The total amount of propofol in group B decreased obviously(P <0.05),duration of recovery and extubation of group B was shorter(P < 0.05). The recovery of consciousness,tid-al volume and respiratory rate of group B was faster than others. Incidence of hypoxemia was lower in group B(P <0.05). Conclusion BIS-guided TCI with propofol and remifentanil for interventional,which can improve the sur-gical safety and anesthetic accuracy,is suitable for interventional embolization therapy of cerebral aneurysm.