Research progression of MLLT6 in leukemia / 实用肿瘤学杂志

ABSTRACT

MLLT6(Myeloid/Lymphoid or mixed-lineage leukemia(Trithorax homolog,Drosophila);Translocated to,6),also known as AF17(ALL1 fused gene from chromosome 17 protein)and located in chromosome 17 long arm 2 zone 1 band(17q21),was originally isolated as a MLL partner gene in leukemia.It has been reported that MLLT6 has the function of maintaining blood pressure stability.MLLT6 synergistically promotes the development of acute myeloid leukemia(AML)as an oncogene or a gene fusion with mixed lineage leukemia(t(11;17)(q23;q21)).This article provides a comprehensive overview of the research progress of MLLT6 and MLL-MLLT6 fusion protein in leukemia.