Research progress of thioredoxin reductase 2 in malignant tumor / 实用肿瘤学杂志

ABSTRACT

Thioredoxin reductase (TrxR),a family of antioxidant family member,is widely distributed in the body.Its main function is to regulate the redox status of enzymes and transcription factors at the cellular level,and to participate in cell growth,pro-liferation and apoptosis.Meanwhile,it also provides favorable conditions for the occurrence and deterioration of malignant tumors.TrxR has three kinds of isoenzymes.TrxR2 distributed in mitochondria is also up-regulated in most malignant tumors and its expression is much higher than that in paracancerous tissues and normal tissues in recent studies.In addition,there is a lot of correlation between the up-regulated expression of TrxR2 and clinicopathological features as well as prognosis of many malignant tumors.It is speculated that TrxR2 may be involved in the occurrence, deterioration and metastasis in malignant tumors.This article reviews the progress of TrxR2 in several malignancies to explore whether or not TrxR2 can be a biomarker of malignancy and serve as a novel target for oncol-ogy treatment.