Study on the Inhibitory Effect and Mechanism of Guizhi Fuling Pill on Angiogenesis in Rats with Endometriosis / 现代医院
Modern Hospital
;
(6): 725-727, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-698911
ABSTRACT
Objective To analyze and discuss the specific effect and mechanism of Guizhi Fuling pill on angiogenesis in rats with endometriosis. Methods A rat model of endometriosis was established in 40 rats in the same batch, they were randomly divided into 4 groups. The model control group did not give any drugs; the low dose of Guizhi Fuling pill group was given 0. 5 g Guizhi Fuling pill every day; the high dose of Guizhi Fuling pill group was given 3. 0 g cinnamon Fuling pill every day; gestation three ketone group was given three ketene 2 g every day. After 4 weeks of continuous administration, the rats were killed and the expression of VEGF and HIF-1 alpha in the rats was determined. The mechanism of Guizhi Fuling pill in the treatment of endometriosis was determined through the expression of VEGF and HIF-1α. Results Guizhi Fuling pill significantly inhibited the level of intravascular VEGF in rat endometriosis and inhibited the level of mRNA expression of HIF-1α. Conclusion Guizhi Fuling pill can inhibit the angiogenesis of endometriosis, and its mechanism is related to the inhibition of VEGF and HIF-1 alpha.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Modern Hospital
Ano de publicação:
2018
Tipo de documento:
Artigo
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