Research progress of intracellular high mobility group box B1 / 中国小儿急救医学

ABSTRACT

High mobility group box 1 ( HMGB1 ) is a highly conserved DNA-binding protein. The function of HMGB1 varied according to its molecular localization. Meanwhile,HMGB1 is located in the nu-cleus under physiological conditions. It contains stable nucleosome structure and can promote gene recombina-tion,repair,transcription etc,known as the"DNA chaperone". Intracellular HMGB1 has a protective effect on heart hypertrophy, heart failure, pancreatitis, hepatic ischemia/reperfusion injury, spinocerebellar ataxia and other protective effects.