Influence of metoprolol combined Wenxin granule on vascular endothelial function and levels of MCF-6 and PGI2 in patients with chronic heart failure / 心血管康复医学杂志

ABSTRACT

Objective: To observe influence of metoprolol combined Wenxin granule on vascular endothelial function, plasma levels of mitochondrial coupling factor-6 (MCF-6) and prostaglandin I2 (PGI2) in patients with chronic heart failure (CHF). Methods: A total of 164 CHF patients treated in our hospital were selected. They were randomly and equally divided into metoprolol group and combined treatment group (received metoprolol combined Wenxin granule treatment), both groups were treated for 10 weeks. Cardiac function, vascular endothelial function and levels of MCF-6 and PGI2 were measured and compared between two groups before and after treatment. Results: Compared with before treatment, after treatment, there were significant improvement in cardiac function and vascular endothelial function, significant reduction in MCF-6 level and significant rise in PGI2 level in two groups, P=0. 001 all; compared with metoprolol group, there were significant reductions in heart rate [(74. 6±3. 5) beats/ min vs. (67. 5±3. 2) beats/min], left ventricular end-diastolic dimension [(55. 3±5. 1) mm vs. (51. 3± 4. 2) mm], levels of resistin [(29. 5±2. 7) μg/L vs. (23. 3±1. 9) μg/L], endothelin 1 [(71. 0±6. 2) mg/L vs. (56. 7± 5. 3) mg/L]and MCF-6 [(305. 0±27. 7) pg/ml vs. (265. 8±25. 3) pg/ml], and significant rise in left ventricular ejection fraction [(46. 6±4. 4) ％ vs. (50. 7±5. 1) ％], levels of calcitonin gene related peptide [(42. 2±3. 6) mg/ L vs. (51. 4±6. 3) mg/L], nitric oxide [(73. 3±6. 9) mg/L vs. (89. 4±7. 6) mg/L]and PGI2 [(20. 6±3. 5) pg/ ml vs. (24. 3±3. 6) pg/ml]in combined treatment group, P=0. 001 all. Conclusion: Metoprolol combined Wenxin granule can significantly improve cardiac function and vascular endothelial function, inhibit release of plasma mitochondrial coupling factor-6 and increase prostaglandin level in patients with chronic heart failure.