Influence of Xingnaojing injection on levels of NO ,IGF-1 ,MIF and it therapeutic effect in patients with hypertensive cerebral hemorrhage / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of Xingnaojing injection on levels of nitric oxide (NO) ,insulin-like growth fac-tor 1 (IGF-1) ,macrophage migration-inhibitory factor (MIF) and its therapeutic effect in patients with hypertensive cere-bral hemorrhage (HCH).Methods:A total of 96 HCH patients treated in our hospital were selected .According to random number table ,they were randomly and equally divided into routine treatment group and Xingnaojing group ,both groups were treated for two weeks .Levels of serum inflammatory factors ,NO ,IGF-1 ,MIF and United states national institutes of health stroke score (NIHSS) before and after treatment ,and therapeutic effect were compared between two groups .Re-sultsCompared with before treatment ,after treatment ,there were significant reductions in levels of CRP ,TNF-α ,IL-6 , MIF and NIHSS score ,and significant rise in levels of NO and IGF-1 in two groups ,P＝0.001 all ;compared with routine treatment after treatment ,there were significant reductions in levels of CRP [ (18.59 ± 4.90) mg/L vs.(12.48 ± 2.56) mg/L] ,TNF-α [ (29.45 ± 5.80) μg/ml vs.(23.02 ± 6.89) μg/ml] ,IL-6 [ (97.56 ± 21.25) μg/ml vs.(88.56 ± 20.12) μg/ml] ,MIF [(50.78 ± 4.90) ng/L vs.(42.02 ± 6.12) ng/L] and NIHSS score [(7.45 ± 2.23) scores vs.(5.12 ± 1.23) scores] ,and significant rise in levels of NO [ (43.56 ± 5.88) μmol/L vs.(50.46 ± 6.39) μmol/L] and IGF-1 [ (55.78 ± 6.03) nmol/L vs.(61.56 ± 8.02) nmol/L] in Xingnaojing group , P＜0.05 or ＜0.01. After treatment ,total effective rate of Xingnaojing group was significantly higher than that of routine treatment group (93.75% vs.72.92%,P＝0.006). Conclusion: Xingnaojing injection can significantly reduce inflammation level ,improve cerebral neurological function and clinical therapeutic effect in HCH patients .