Influence of Danhong injection combined metoprolol tartrate on hemodynamics and ECG in CHD pa-tients with arrhythmias / 心血管康复医学杂志

ABSTRACT

Objective:To analyze influence of Danhong injection combined metoprolol tartrate on hemodynamics and ECG in patients with coronary heart disease (CHD) and arrhythmias .Methods:A total of 98 CHD patients with ar-rhythmias treated in our hospital from Feb 2013 to Sep 2016 were selected .The patients were randomly divided into routine treatment group and combined treatment group (received Danhong injection combined metoprolol tartrate based on routine treatment group ) ,both groups were treated for continuous four weeks .Blood pressure etc .indexes and therapeutic effect were observed and compared between two groups before and after treatment .Results: Com-pared with before treatment ,after four-week treatment ,there were significant reductions in systolic blood pressure (SBP) ,diastolic blood pressure (DBP) ,mean arterial pressure (MAP) ,times of non-sustained ventricular tachycar-dia (NSVT) and ventricular premature beat (VPB) ,erythrocyte sedimentation rate (ESR) ,fibrinogen (Fg) ,hem-atocrit (HCT) ,whole blood low shear viscosity (NBL) and whole blood high shear viscosity (NBH) ,and significant rise in PR interval in two groups ,and significant rise in QT interval in combined treatment group , P＜0. 05 or ＜0.01. Compared with routine treatment group after four-week treatment ,there were significant reductions in levels of SBP [ (120.11 ± 10.23) mmHg vs.(108.11 ± 7.83) mmHg] ,DBP [ (85.61 ± 5.61) mmHg vs.(70.12 ± 4.12) mmHg] ,MAP [ (100.11 ± 7.23) mmHg vs .(81.33 ± 5.16) mmHg] ,times of NSVT [ (4.51 ± 0.31) times/d vs. (2.11 ± 0.25) times/d] and VPB [ (3673.11 ± 86.34) times/d vs.(2711.34 ± 62.31) times/d] ,ESR [ (19.72 ± 2.73) mm/h vs.(12.44 ± 1.98) mm/h] ,Fg [ (300.11 ± 23.44) g/L vs.(223.43 ± 16.74) g/L] ,HCT [ (40.12 ± 3.57)% vs.(31.32 ± 2.14)% ] ,NBL [ (8.22 ± 1.11) mpa·s vs .(6.72 ± 0.84) mpa·s] and NBH [ (5.12 ± 0.73) mpa·s vs .(3.98 ± 0.56) mpa·s] ,and significant rise in QT interval [ (0.38 ± 0.17) s vs .(0.49 ± 0.19) s] ,PR interval [ (0.17 ± 0.02) s vs.(0.19 ± 0.03) s] and QRS interval [ (0.07 ± 0.02) s vs.(0.09 ± 0.03) s] in combined treatment group , P＜0. 01 all.Total effective rate of combined treatment group was significantly higher than that of routine treatment group (89.80% vs.73.47%) , P＝0.035 .Conclusion:Danhong injection combined metoprolol tartrate can significantly improve hemodynamic and ECG indexes in CHD patients with arrhythmias , which is worth extending .