Influence of lyophilized rhBNP on Chemerin and Gal-3 levels in aged AMI patients / 心血管康复医学杂志

ABSTRACT

Objective :To explore influence of lyophilized recombinant human brain natriuretic peptide (rhBNP) combined routine treatment on levels of Chemerin (a new adipocytokine) and Galectin (Gal)-3 in aged AMI patients.Methods :A total of 120 aged AMI patients treated in our hospital were randomly and equally divided into routine treatment group and rhBNP group (received rhBNP based on routine treatment ) ,both groups were treated for 3d.Vascular endothelial func-tion ,levels of Chemerin and Gal-3 before and after treatment and incidence rate of adverse reactions within one year were observed and compared between two groups .Results :Compared with before treatment ,after treatment ,there were signifi-cant rise in fore brachial artery endothelium dependent diastolic-systolic function (FMD) and NO level ,and significant re-ductions in levels of ET-1 ,Chemerin and Gal-3 in two groups ,P＝0.001 all.Compared with routine treatment group after treatment ,there were significant rise in FMD [ (9.5 ± 2.5)% vs.(14.1 ± 3.4)%] and NO level [ (37.2 ± 3.1) μmol/L vs.(43.2 ± 5.7) μmol/L] ,and significant reductions in levels of ET-1 [ (72.1 ± 9.9) ng/L vs.(61.8 ± 8.5) ng/L] , Chemerin [ (25.2 ± 3.8) μg/ml vs.(16.9 ± 4.2) μg/ml] and Gal-3 [ (9.3 ± 1.4) ng/ml vs.(6.7 ± 1.2) ng/ml] in rhB-NP group ,and each HRV index of rhBNP group was significantly higher than that of routine treatment group , P＝0.001 all.Compared with routine treatment group after one-year follow-up , there were significant reductions in mortality (13.3% vs.1.7%) and incidence rate of cardiac insufficiency (18.3% vs.5.0%) in rhBNP group , P＜0.05 both .Con-clusion :Lyophilized rhBNP can significantly improve vascular endothelial function and HRV , reduce serum levels of Chemerin and Gal-3 and improve prognosis in AMI patients .