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Research progress of pathological relevant cytokines of neovascular eye diseases / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology ; (12): 636-642, 2018.
Artigo em Chinês | WPRIM | ID: wpr-699794
ABSTRACT
Neovascular eye diseases,with highly complicated and refractory,are one group of the most difficult problems for domestic and overseas clinical oculists in recent years.Angiogenesis is a complex process participating with multiple factors and various ways,and its exact pathogenesis is unclear yet.Ocular neovascularization is the dynamic balance result between proangiogenic factors and antiangiogenic factors provided that intraocular microenvironment be under a physiological condition.Some pathological factors including ischemia,hypoxia and inflammation destroy the dynamic balance between cytokines leading to neovascularization.Currently studies indicated that numerous cytokines containing vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) are closely linked to ocular neovascularization,while it is more crucial to elucidate the molecular mechanism of numerous cytokines involved in ocular neovascularization,which can recognize the pathogenesis of neovascular eye disease more clearly.Research progress of pathological relevant cytokines of neovascular eye diseases,including VEGF,insulin-like growth factor 1 (IGF-1),angiogenin-2 (Ang-2),stromal cell derived factor 1 (SDF-1) and PEDF were reviewed in this paper.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Experimental Ophthalmology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Experimental Ophthalmology Ano de publicação: 2018 Tipo de documento: Artigo