Expression of serum S100 calcium binding protein in preterm premature rupture of membrane / 中国医师进修杂志

ABSTRACT

Objective To study the role of serum S100 calcium binding protein (S100A12) in preterm premature rupture of membrane induced chorioamnionitis. Methods Thirty-six patients with preterm premature rupture (preterm premature rupture group), 48 patients with term birth premature rupture (term birth premature rupture group) and 17 normal pregnant women (control group) were selected. The blood routine, S100A12, C response protein (CRP), glycohemoglobin (GHB) levels were detected and compared. Results The S100A12 in preterm premature rupture group was significantly higher than that in term birth premature rupture group and control group (1 193.6 ± 443.1) ng/L vs. (787.7 ± 482.6)and(610.5 ± 449.0)ng/L,and there was statistical difference(P<0.01);but there was no statistical difference between term birth premature rupture group and control group(P<0.05).In preterm premature rupture group, S100A12 levels in the gestational diabetes mellitus (GDM) and non-GDM patients were significantly higher than those in control group(1 225.4 ± 422.5)and(1 168.2 ± 468.2)ng/L vs. (610.5 ± 449.0) ng/L, and those in GDM patients were significantly higher than those in non-GDM patients, and there were statistical differences (P<0.05). In preterm premature rupture group, the S100A12 showed significant positive correlation with CRP, neutral granulocyte percent and GHB (r =0.236, 0.222 and 0.378; P<0.05 or <0.01). Conclusions S100A12 would have an important role in the mechanism of preterm premature rupture of membrane combined with GDM induced chorioamnionitis.