The function and association between PD-L1 and Treg cells in tumor immunity / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 198-203, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-700802
ABSTRACT
Programmed death-1 (PD-1) is the member of the inhibitory costimulatory molecules,has its ligand (programmed death ligand 1,PD-L1),expressing on the surface of a variety of tumor cells.PD-1/PD-L1 plays an important role in the negative regulation of immune responses,promoting tumor immune escape.Regulatory T cell (Treg) is a kind of T cell subsets with immunosuppressive effect,which is highly expressed in tumor tissues,and plays a role in immune tolerance.Recent studies demonstrate key roles of PD-L1 in promoting iTreg cell development and function.This paper gives a brief review of their immune regulations and the association between PD-L1 and Treg.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2018
Tipo de documento:
Artigo
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