Progress in study of long non-coding RNA UCA1 in tumors / 医学研究生学报

ABSTRACT

Urothelial carcinoma associated 1 was initially discovered and confirmed that was specifically high expressed in bladder cancer.The aberrant expression of UCA1 was reported in various tumors,especially in tumors occurred in digestive system and urogenital system.Recently,more and more advances have indicated that UCA1-overexpressed in a larger number tumors to play oncongenic roles in tumor onset,progression,and metastasis.However,the molecular mechanism of UCA1 in cancer development,progression and metastasis remains to be further explored.In this review,we focus on structure and isoforms of UCA1,function and mechanism for UCA 1 tumor-promoting effect.We further discuss the potential clinical application of UCA1 as a promising diagnostic biomarker or therapeutic target for human tumors.