Focusing on the role of histone modification during carcinogenesis, promoting the study on the epigenetic target of arsenic / 中华地方病学杂志

ABSTRACT

The mechanisms by which arsenic induces tumorigenesis have not been fully elucidated. Genetics is involved in the carcinogenesis induced by arsenic. As an important epigenetic mechanism, histone modifications play a critical role in the carcinogenesis and development of tumor. However, there is still less research on the role of histone modifications during the carcinogenesis of arsenic. So, further studies on the possible role of histone modifications in arsenic carcinogenesis not only enrich the epigenetic targets of arsenic,but also have important implications for the elucidation of the mechanism of arsenic carcinogenesis.