Analysis of clinical features and prognosis, 590 cases of Brucellosis in Xinjiang China / 中华地方病学杂志

ABSTRACT

Objective To analyze the clinical data of brucellosis, provide the references for brucellosis therapy. Methods The patients definitely diagnosed brucellosis at the First Affiliated Hospital of Xinjiang Medical University from 2005 to 2015 were assessed, data of clinical features, laboratory examination, complications, treatment and prognosis were analyzed. Results Of all 590 cases,the mean age was(44.24 ± 15.83)years old,the range was 3-75 years old,357(60.51%) cases had a history of raising and closely contacted with cattle and sheep, acute phase in 316(53.56%)cases,and chronic phase in 127(21.53%).The most common symptoms were fatigue in 537 (91.02%) cases, sweating in 520 (88.14%), fever in 513 (86.95%) and arthralgia in 478 (81.02%). Serum test tube agglutination test was positive in 583 (98.81%), blood culture was positive in 159 (33.97%,159/468).After patients receive antimicrobial treatment, body temperature decreased in 2 - 14 d. The overall recurrence rate was 5.98%(28/468),those patients with osteoarticular involvement even reached 23.22%(137/590).Doxycycline combined with rifampicin was the most common used antibiotics regimen, triple antibacterial drug program was recommended for patients with comorbidities. Conclusions The clinical manifestations of brucellosis is diversity, fatigue, sweaty, fever and arthralgia are the most common symptoms, and osteoarticular is the most frequently involved. Serum agglutination test is an important method in diagnosis of the disease, and combination of antibacterial drugs therapy is recommended.