Effects of deoxynivalenol on articular cartilage injury / 中华地方病学杂志

ABSTRACT

Deoxynivalenol (DON) is one of mycotoxins produced by fungal pathogen of fusarium,which has strong cytotoxicity.The study of articular cartilage injury is focused on the study of Kaschin-Beck disease (KBD)pathogenesis.DON can inhibit the proliferation of chondrocytes,induce apoptosis,affect the cell-related metabolic enzymes and other ways to break the balance of chondrocytes and extracellular matrix,eventually leading to irreversible damage of articular cartilage.This article reviews the role of DON toxin in the cartilage injury.