Effect of compound glycyrrhizin on alcoholic fatty liver disease / 中国基层医药

ABSTRACT

Objective To observe the clinical effect of compound glycyrrhizin in the treatment of alcoholic fatty liver disease(AFLD).Methods 68 AFLD patients according to the different treatment methods were divided into two groups.34 cases in the control group received conventional therapy ,34 cases in the observation group were given compound glycyrrhizin based on the conventional treatment .The clinical effect of the two groups was compared . Results The total effective rate of the observation group was 91.18%,which was higher than 64.71% of the control group,the difference was statistically significant (χ2 =6.928,P <0.05).The TBIL,GGT,AST,ALT of the observation group were (6.39 ±1.15)μmol/L,(157.79 ±17.39)U/L,(37.49 ±2.61)U/L,(24.45 ±2.16)U/L,respectively, which of the control group were (26.14 ±2.79)μmol/L,(417.59 ±45.89)U/L,(97.28 ±11.39)U/L,(54.33 ± 4.05) U/L,respectively,the differences between the two groups after treatment were statistically significant ( t =41.392,33.482,32.361,41.171,all P <0.05).The incidence rate of adverse reactions of the observation group was 5.88%,which was lower than 26.47% of the control group (χ2 =4.250,P <0.05).Conclusion Compared with conventional treatment,compound glycyrrhizin in the treatment of AFLD can effectively improve the patients 'TBIL, GGT,AST,ALT index,improve the clinical efficacy.