Effect of 3 ％ sodium chloride injection in the treatment of fluid resuscitation in children with sepsis shock / 中国基层医药

ABSTRACT

Objective To investigate the effect of 3％ sodium chloride injection on fluid resuscitation in children with septic shock.Methods Eighty-four children with sepsis in intensive care unit were selected and divided into two groups according to random number table method,42 cases in each group.The control group was treated with 0.9％ sodium chloride injection for fluid resuscitation.The observation group was slowly given 3％ sodium chloride injection for fluid resuscitation.The changes of the two groups were observed.The success time of fluid resuscitation,hospitalization time and success rate of the two groups were compared.Results After intervention,the systolic blood pressure,central venous pressure and 24h urine output in the observation group were (85.6 ± 4.3) mmHg,(7.1 ± 0.5) cmH2O,(250.8 ± 11.9) mL,respectively,which in the control group were (66.9 ± 2.6)mmHg,(4.6 ±0.2)cmH2O,(50.1 ± 5.0)mL,respectively,the differences between the two groups were statistically significant (t =23.536,29.361 and 98.339,all P ＜ 0.05).The success time of fluid resuscitation,hospitalization time of the observation group were (6.7 ± 1.1) h,(4.1 ± 0.2) d,respectively,which were significantly shorter than those of the control group [(18.5 ± 2.3) h,(6.3 ± 0.5) d,t =29.272,25.838,all P ＜ 0.05).The success rate of treatment of the observation group (95.0％) was higher than that of the control group (65.0％) (x2 =7.941,P ＜ 0.05).Conclusion 3 ％ sodium chloride injection can effectively treat fluid resuscitation,improve tissue perfusion,shorten the hospitalization time and improve the success rate of treatment for children with septic shock.