Analysis of the effect of oxygen driven aerosol inhalation in the treatment of acute exacerbation of bronchial asthma / 中国基层医药

ABSTRACT

Objective To analyze the effect of oxygen driven aerosol inhalation in the treatment of acute exacerbation of bronchial asthma .Methods 96 patients with acute exacerbation of bronchial asthmawere selected as the subjects .They were divided into observation group and control group by the random number table ,48 cases in each group.All patients were treated with salbutamol and budesonide inhalation therapy ,the control group was treated with ultrasonic atomization inhalation ,the observation group was treated with oxygen driven aerosol inhalation .The changes of blood oxygen saturation ( SpO2 ) ,maximum expiratory peak flow ( PEF) ,forced expiratory volume in the first second ( FEV1 ) and respiratory index ( RI) were observed before and after treatment in the two groups .The time of disappear-ance of major clinical symptoms was compared ,and the clinical treatment effect was analyzed .Results After treat-ment,the total effective rate of the observation group was 91.67％,which of the control group was 72.92％,the differ-ence between the two groups was statistically significant (χ2 =7.19,P<0.05).Compared with the control group ,the fever,cough,asthma,wheezing,shortness of breath,pulmonary rales and main clinical symptoms disappear time of the observation group were significantly shortened [observation group(3.05 ±1.23)d,(4.43 ±1.16)d,(3.12 ± 1.11)d,(4.26 ±1.37)d,(4.98 ±1.75)d,(3.51 ±1.37)d;control group(4.14 ±1.03)d,(7.75 ±1.98)d, (5.75 ±1.86)d,(6.53 ±1.46)d,(8.42 ±1.55)d,(6.53 ±1.46)d,t=4.71,10.02,8.41,7.86,10.20,10.45, all P<0.01].After treatment,the SpO2,PEF and FEV1 of the two groups were significantly increased [observation group( 98.70 ±1.44 )％, ( 126.33 ±9.87 ) mL/min, ( 2.06 ±0.52 ) L;control group( 83.15 ±1.39 )％,(108.32 ±7.26)mL/min,(1.42 ±0.38)L],while RI decreased significantly[observation group(0.17 ±0.08), control group(0.27 ±0.06),the differences were significant (to =36.18,16.77,12.04,10.69,tc =11.03,8.15, 5.34,2.69,all P<0.01),and the improvement of SpO2,PEF,FEV1 and RI of the observation group were significantly better than those of the control group (t=53.8310.18,6.88,6.74,all P<0.01).Conclusion In the treatment of acute exacerbation of bronchial asthma ,the clinical efficacy of oxygen driven aerosol inhalation is significant .The way can better alleviate patients'major clinical symptoms,such as fever,cough,improve lung ventilation function,and is worthy of further clinical application .