Effect of oral probiotics in the treatment of nonalcoholic fatty liver disease / 中国基层医药

ABSTRACT

Objective To investigate the clinical value of probiotics in the treatment of patients with nonal -coholic fatty liver disease ( NAFLD) .Methods The clinical data of 100 patients with NAFLD were retrospectively analyzed.According to different treatment methods ,the patients were divided into two groups ,with 50 cases in each group.The control group received basic treatment ,the observation group received probiotics treatment on the basis of the control group .The treatment effects of the two groups were analyzed .Results The total effective rate in the obser-vation group (54.00%) was significantly higher than that in the control group (30.00%)(χ2 =5.911,P=0.015) .After treatment,the ALT,TG,HOMA-R,TNF-α,D-lactic acid,endotoxin levels in the observation group were significantly better than those in the control group (all P<0.05).The incidence rate of adverse reactions between the two groups had no statistically significant difference (4.00% vs.2.00%,χ2 =0.343,P =0.558).Conclusion Probiotics in the treatment of NAFLD can reduce the intestinal permeability ,improve the intestinal endotoxemia and the prognosis of the patients .