Clincal significance of detection of FeNO levels applicated in the treatment of patients with bronchial asthma / 中国基层医药

ABSTRACT

Objective To investigate the role of exhaled nitric oxide (FeNO) detection in patients with bron-chial asthma,and to observe the correlation between FeNO level and pulmonary function .Methods The clinical data of 61 patients with acute exacerbation of bronchial asthma were retrospectively analyzed .The patients were included in the case group .According to the disease condition ,the patients were divided into mild asthma group ( 30 cases ) and moderate asthma group (31 cases).A total of 60 healthy people were selected as the control group .All the patients were given corresponding symptomatic treatment ,before and after treatment ,the FeNO and lung function were deter-mined in two groups.Results After treatment,the level of FeNO in the mild asthma group was (22.22 ±8.39)ppb, which was significantly lower than (35.21 ±10.84)ppb in the moderate asthma group (t=5.22,P=0.00).The levels of FEV1 and PEF in the mild asthma group were (2.49 ±0.38)%,(3.82 ±0.24)L/min,respectively,which in the moderate asthma group were (2.52 ±0.41)%,(3.74 ±0.35)L/min,respectively,the differences between the two groups were not statistically significant (t=0.29,1.03,P=0.76,0.30).The FeNO levels of the two groups after treatment were significantly lower than those before treatment ,and the FEV1 ,PEF levels were significantly higher than those before treatment (all P<0.05).Before treatment,the levels of FeNO,FEV1 and PEF in the case group were(50.41 ±30.09) ppb,(1.98 ±0.37)%,(3.24 ±0.36) L/min,respectively,which in the control group were (12.59 ±6.39)ppb,(2.79 ±0.34)%,(4.02 ±0.18)L/min,respectively,the differences were statistically signifi-cant between the two groups (t=9.52,12.53,15.03,P=0.00,0.00,0.00).After treatment,the levels of FeNO, FEV1 and PEF in the case group were (23.52 ±10.54)ppb,(2.81 ±0.35)%,(3.91 ±0.40)L/min,respectively, which in the control group were (12.59 ±6.39)ppb,(2.79 ±0.34)%,(4.02 ±0.18)L/min,respectively,the difference of FeNO between the two groups was statistically significant (t=6.88,P=0.00),the differences of FEV1 and PEF were not statistically significant between the two groups (t=0.31,1.94,P=0.75,0.05).The difference of FeNO between males and females was not statistically significant (P >0.05).There was a negative correlation between FeNO and FEV1 before treatment(r=-0.172,P=0.02),and FeNO negatively correlated with FEV (r=-0.163,P=0.01).There was no correlation between FeNO and FEV 1 after treatment(r=-0.031,P=0.754), independent of FEV(r=-0.141,P=0.09).Conclusion The level of FeNO is helpful to evaluate the severity of airway inflammation and lung function in bronchial asthma patients , and it is not related to sex .FeNO level is negatively correlated with pulmonary function ,and is helpful to evaluate the clinical efficacy .