Analysis of clinical characteristics and related factors of feeding intolerance in preterm infants / 中国基层医药

ABSTRACT

Objective To analyze the clinical characteristics and risk factors of feeding intolerance in preterm infants.Methods From March 2015 to February 2017,a total of 156 preterm infants in the Central Hospital of Rizhao were selected.Of them,96 feeding intolerance premature infants were selected as the observation group,and 60 feeding tolerance premature infants were selected as the control group.The clinical characteristics of the two groups were analyzed,and the risk factors of feeding intolerance in preterm infants were analyzed by logistics multivariate analysis.Results In the infants with gestational age ＜30 weeks,abdominal distension(34.6%)and gastric reten-tion(50.0%)had the highest incidence rate.In the infants with gestational age 33 －37 weeks and weighing more than 2 500g,the incidence rate of vomiting (45.0%)was highest.In the infants with open milk time no less than 72h,the incidence rate of vomiting(39.3%),abdominal distension(35.7%),gastric retention(44.6%)were signifi-cantly higher than those of the infants with open milk time less than 72h.In the infants with gestational age ＜30 weeks,the proportion of hypoglycemia(23.1%),significantly reduced body mass(19.2%)were significantly higher than those of the other gestational age,the differences were statistically significant(χ2＝5.682,4.235,3.452,4.763, 5.526,3.984,6.224,5.341,all P＜0.05).Compared with the control group,in the observation group,the gestational age[(30.4 ±1.3)weeks vs.(33.6 ±2.6)weeks]was smaller,birth weight[(1693 ±467)g vs.(1868 ±537)g]was lower,open milk time[(46.8 ±18.8)h vs.(32.7 ±17.7)h]and defecation time[(58.6 ±12.8)h vs.(39.6 ± 10.6)h]were later,the proportion of the use of respirator(32 cases vs.9 cases),premature rupture of membranes (26 cases vs.6 cases),early pregnancy(51cases vs.15 cases)and perinatal diseases(49 cases vs.12 cases)were higher,the differences were statistically significant(t ＝5.675,4.967,9.367,7.678,χ2＝6.523,5.564,6.652, 7.157,all P＜0.05).Logistics multivariate analysis showed that gestational age ＜33 weeks,birth weight＜1500 g, open milk time＞3d,ventilator and preterm infants were independent risk factors for feeding intolerance in preterm infants.Conclusion The common clinical manifestations of feeding intolerance in premature infants include vomi-ting,abdominal distension and gastric retention.Gestational age less than 33 weeks,birth weight＜1500 g,open milk time＞3d,ventilator and preterm infants are independent risk factors for feeding intolerance in preterm infants.