Curative effect of sclerotherapy injection combined with somatostatin on esophageal variceal bleeding / 中国基层医药

ABSTRACT

Objective To explore the effect,safety and prognosis of sclerotherapy combined with somatostatin in the treatment of esophageal varicose hemorrhage.Methods From January 2014 to January 2017, a total of 100 patients with esophageal varicose hemorrhage in the Central Hospital of Yiwu were selected ,and they were divided into control group and observation group according to the digital table ,with 50cases in each group.The control group was treated with somatostatin alone , the observation group was treated with somatostatin combined with hardener injection.The clinical efficacy, safety and prognosis were compared between the two groups.Results Before treatment,the esophageal varices width had no statistically significant difference between the two groups ( t＝0.86, P＞0.86).After treatment,the esophageal varices width of the two groups were improved ( t＝2.64,4.82,all P＜0.05),the esophageal varices width of the observation group [(0.74 ±0.32)cm] was significantly better than (0.93 ± 0.32)cm of the control group (t＝2.31,P＜0.05).The blood transfusion volume of the observation group [(324.94 ± 37.52)mL] was significantly lower than (512.46 ±62.48)mL of the control group (t＝13.86,P＜0.05).The hemostatic time of the observation group [(15.24 ±2.36)h] was significantly shorter than (21.31 ±3.29)h of the control group (t＝4.65,P＜0.05).The hospitalization time of the observation group [(11.73 ±2.39) d] was significantly shorter than (20.75 ±3.46)d of the control group (t＝6.97,P＜6.97).The hemostasis of the observation group was 38 cases,and the hemostatic rate was 76%,which was significantly higher than 52% of the control group (χ2＝5.63,P＜0.05).The number of patients with postoperative fever ,poststernal pain,swallowing obstruction,sick and vomit,palpitation in the observation group was lower than those in the control group ,but there was no statistically significant difference (χ2＝0.95,1.03,0.86,1.25,0.92,all P＞0 0.05).The incidence rate of adverse reaction of the observation group was 22%,which was lower than 40%of the control group (χ2＝6.43,P＜0.05).The rebleeding rate of the observation group was 12%,which was significantly lower than 34%of the control group (χ2＝5.63,P＜0.05).Conclusion The injection of sclerosing agent in the treatment of esophageal varicose hemorrhage has good clinical efficacy, safety, less complications and better prognosis , which is worthy of application and widespread promotion.