Clinical study on conbercept combined with minimally invasive vitrectomy in the treatment of patients with diabetic retinopathy / 中国基层医药

ABSTRACT

Objective To investigate the application effect of conbercept combined with minimally invasive vitrectomy in the treatment of patients with diabetic retinopathy .Methods From September 2015 to June 2017 , A total of 81 cases (81 eyes) of diabetic retinopathy in the People's Hospital of Changzhi were divided into two groups according to the random number table ,40 cases in the control group treated with 25 G minimally invasive vitrectomy , and 41 cases in the observation group treated with intravitreal injections of conbercept +25G minimally invasive vitrectomy.The filling rate of intraocular fillers,intraocular pressure (IOP),best corrected visual acuity (BCVA),and the change of retinal thickness before and after operation were observed and compared in two groups .The changes of serum levels of stromal cell derived factor -1 ( SDF-1 ) and β2-glycoprotein Ⅰ(β2-GPⅠ) before and after operation and complications were compared between the two groups .Results The filling rate of intraocular fillers in the observation group was 12.20％(5/41),which was lower than that in the control group [30.00％(12/40)],and the difference was statistically significant (χ2 =3.871,P=0.049).Three months after operation ,the BCVA in the observation group was higher than that in the control group ,and the thickness of the retina was smaller than that in the control group,the differences were statistically significant (t1=4.352,P1 =0.000;t2 =9.709,P2 =0.000).The serum levels of β2-GP I and SDF-1 in the observation group were lower than those in the control group at 5 days after operation,and the differences were statistically significant (t1=22.978,P1=0.000;t2=26.875,P2=0.000). The incidence rate of complication in the observation group was 7.32％ (3/41),which was lower than that in the control group 25.00％ (10/40),and the difference was statistically significant (χ2 =4.699,P =0.030). Conclusion Conbercept combined with minimally invasive vitrectomy in the treatment of patients with diabetic retinopathy can reduce the thickness of retina and the serum levels of β2-GP Ⅰ and SDF -1.The filling rate of intraocular fillers in the patients is low ,and it can help to improve the visual function of the patients and reduce the incidence of complications .