Curative effect of indapamide combined with amlodipine in the treatment of hypertension complicated with coronary heart disease / 中国基层医药

ABSTRACT

Objective To explore the clinical effect of indapamide combined with amlodipine in the treatment of hypertension complicated with coronary heart disease (CHD).Methods From January 2015 to January 2017,62 hypertension patients complicated with CHD in the First People's Hospital of Daishan County were selected in the research.The patients were randomly divided into two groups according to the digital table ,with 31 cases in each group.The observation group received indapamide combined with amlodipine therapy ,and the control group received nifedipine controlled release tablets .The curative effect was compared between the two groups .Results After treatment,the treatment effective rate of the observation group was 93.55%,the incidence rate of adverse reactions of the observation group was 9.68%,which of the control group were 83.87%,25.81%,respectively.The differences were significant in therapeutic effect ,total cholesterol ,angina frequency,triglycerides,systolic pressure,diastolic blood pressure between the two groups (χ2＝8.226,t＝8.226,6.223,7.112,5.012,5.348,all P＜0.05).Conclusion Amlodipine in combination with indapamide in the treatment of hypertension complicated with CHD can reduce blood pressure,better auxiliary lower total cholesterol and triglyceride levels ,avoid attack frequency of angina pectoris ,and with no increase in adverse drug reactions ,it has a certain clinical significance .