Analysis of Motor Function in Patients with Duchenne Muscular Dystrophy / 中国康复理论与实践

ABSTRACT

Objective To analyze the differences of motor function between Chinese patients with Duchenne muscular dystrophy (DMD)and normal children,and to explore the changes of motor function in Chinese DMD patients. Methods From April,2016 to August,2017,155 DMD patients(DMD group)and 24 normal boys(control group)were given 6-minute walk test,timed rise from floor test,4-stair test,and 9 meters walking time test. Results The 6-minute walk distance(6MWD)was lower in DMD group than in the control group(t=-9.534,P<0.001), and the 9 meters walking time was higher in DMD group than in the control group(t=-7.460,P<0.001).There was no significant difference in 6MWD and 9 meters walking time between two groups at the age of 6.0 to 6.9 years(P>0.05);however,the difference was significant after seven years old(t>2.648,P<0.001).The completion times of timed rise from floor test and 4-stair test group were distributed between 1.95 to 27.27 seconds and 1.18 to 19.17 seconds,respectively,in DMD group.The 6MWD decreased from 7.0 years old,and 9 meters walking time increased from 7.2 years old.The completion time of timed rise from floor test increased from 5.2 years old, and the completion time of 4-stair test increased from 5.5 years old. Conclusion The motor function of Chinese DMD patients is worse than normal children at the same age.The age nodes of the movement indicators are different in DMD patients.The timed rise from floor test and the 4-stair test are earlier affected by the disease.