A retrospective study on bone metabolism biochemical markers change in patients with spinal cord injury / 中国康复医学杂志

ABSTRACT

Objective:To investigate the relationship between bone metabolism biochemical markers and clinic features (course,AIS,etc.)in spinal cord injury patients.Method:Totally 73 patients aged from 13 to 89 years with SCI were enrolled.The injury time was recorded,and patients' AIS was assessed.25-hydroxyvitamin D [25(OH)D],collagen type Ⅰ C-terminal telopeptide (CTX)and N-terminal propeptide of type 1 precollagen(P1NP) were measured.Result:In our observation of patients with spinal cord injury,the ratio of 25(OH)D deficience was 98.6％.Correlation between 25(OH)D and clinic features was not found.P1NP showed positive correlation with course (R=-0.235,P＜0.05)and negative correlation with AIS (R=0.442,P＜0.01).CTX showed negative correlation with AIS and age(R was-0.232 and-0.296,P＜0.05).There is no difference between tetraplegia and paraplegia (AIS C and D) in 25(OH)D、P1NP and CTX.CTX is higher in traumatic spinal cord injury patients,(Z=-.2.086,P ＜ 0.05)Conclusion:In patients with spinal cord injury,a lack of vitamin D has a high proportion.The lower AIS was,the higher P1NP and CTX was,which meant severe bone loss.Bone loss may be faster in younger SCI patients and traumatic spinal cord injury patients.