Effects of different glucocorticoids on pulmonary infection in patients with rheumatoid arthritis / 中国免疫学杂志

ABSTRACT

Objective:To compare the effects of different glucocorticoids on the pulmonary infection in patients with rheumatoid arthritis (RA).Methods: From January 2013 to February 2017,128 cases of patients with RA in our hospital were selected as the research object,all the cases were divided into observation group and control group with 64 cases in each group accorded to the random draw envelope principle.The observation group was given intra-articular injection of corticosteroid therapy,the control group was given oral glucocorticoid therapy,two groups were treated for 8 weeks.Results:The total effective rate of the observation group and the control group was 96.9% and 84.4% respectively,and the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The joint pain and joint swelling index of the observation group and the control group after treatment were sig-nificantly lower than that before the treatment (P<0.05),and the joint pain and joint swelling index of the observation group after treatment were significantly lower than that of the control group (P<0.05).The incidence of pulmonary infection in the observation group and the control group during treatment were 1.6% and 7.8%,respectively.The incidence of pulmonary infection in the observation group was significantly lower than that in the control group (P<0.05).The CRP and RF in the observation group after treatment were (10.11±3.19)mg/L and (50.22±19.82)U/ml that were significantly lower than the control group of (17.49±5.32) mg/L and (59.14±20.59)U/ml (P<0.05),while the CRP and RF values of the two groups after treatment was obviously lower than that before treatment (P<0.05).Conclusion: Compare with oral administration,intra articular injection of glucocorticoid for RA can reduce the incidence of pulmonary infection,inhibit the expression of inflammatory factors and RF,and promote the alleviation of clinical symptoms,thereby enhance the therapeutic effect.