Advances in research on nuclear factor of activated T cells with tumor biological behavior / 中国免疫学杂志

ABSTRACT

The NFAT protein signaling pathway plays an important role in the regulation of cell function,such as cell proliferation,differentiation,invasion,metastasis,angiogenesis and tumor microenvironment,and it is also important in the development in embryogenesis,organogenesis,immune response and inflammatory response.Although the NFAT family has been shown to be a key role in the development of tumors,the different isoforms of the NFAT family play a different role in different cells,to understand the role and mechanism of the NFAT family in tumor development and progression will help to develop new strategies for targeting NFAT tumor therapy.