IL-36 in inflammatory diseases / 中国免疫学杂志

ABSTRACT

The IL-36,which is a member of IL-1 family,consists of three ligands IL-36α,IL-36β and IL-36γ. The cytokines exert their proinflammatory effects through a specific IL-36 receptor(IL-36R),IL-36Ra is an antagonist of IL-36R.IL-36 acts as a helper,involved in dendritic cell and T cell activation, maturation, polarization, antigen presentation and stimulating inflammatory factor production,and so on.IL-36,as a new proinflammatory factor,plays a very important role in many inflammation diseases, including psoriasis,inflammatory bowel disease,arthritis,SLE,lung diseases and so on.