Role of dendritic cells in psoriasis formation / 中国免疫学杂志

ABSTRACT

Psoriasis is a common,chronic autoimmune/inflammatory disease directed by abnormal activation of skin immune system.It is characterized by erythematous plaques and slivery scales in the patients'lesional sites.Dendritic cells,macrophages,gamma delta T cells and group 3 innate lymphocytes are great contributors to the progress of the disease,as they are the main source of proin-flammatory cytokines like TNF-α,IL-1β,IL-6,IFN-α,IL-23 and IL-17.Particularly,as the initiator of the inflammation,DCs are indispensable of the progress.There are different subpopulations of dendritic cells in the skin,in this review,we are trying to elaborate their unique location and function based on the published articles.