Effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer's disease / 中国免疫学杂志

ABSTRACT

Objective:To study the effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer's disease. Methods:124 cases alzheimer's patients from October 2014 to October 2016 were divided into observation group and control group,the control group given donepezil etc conventional western medicine therapy,ob-servation group given Yizhi Xingnao Fang combinde with western medicine therapy. 12 weeks after treatment,cerebrospinal fluid in-flammatory factors,neurotransmitter and clinical efficacy were compared between two groups. Results:Observation group effective rate 80.65% was significantly higher than control group 64.52% (X2= 4.052 9,P<0.05);cerebrospinal fluid TNF-α,IL-6 were significantly lower than control group,IL-4,IL-10 were significantly higher than control group (t=10.911,8.739,5.000,4.046,P<0.05,P<0.01);DA,5-HT,NE were significantly higher than control group(t=9.435,7.916,5.985,P<0.05,P<0.01). Conclusion:Yizhi Xingnao Fang combined with western medicine therapy help to improve the clinical symptoms and therapeutic effect,which may be related to the suppression of inflammatory symptoms,regulation of neurotransmitter expression level.