Regulation of hypoxia-inducible factor α in inflammation-associated diseases mediated by innate immune cells / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 929-934, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-702846
ABSTRACT
Hypoxia is a common pathophysiological state especially in the processing inflammatory tissues cells due to hypoxia partial pressure caused by excessive oxygen consumption or insufficient oxygen supply. Hypoxia inducible factor(HIF) that regulates the transcription of downstream target genes in order to cope with the hypoxia environments is induced by various mechanisms in hypoxic state. Studies have demonstrated that HIF-α plays essential roles in the inflammatory response. This paper reviews the recent research that the roles and mechanisms of HIF-α in inflammation-associated diseases mediated by innate immune cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Immunology
Ano de publicação:
2018
Tipo de documento:
Artigo
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