Advances in research of animal models of diabetic foot neuropathy / 中国实验动物学报

ABSTRACT

Diabetic foot with diabetic peripheral neuropathy(DPN)can lead to peripheral nerve dysfunction. Ex-ploring appropriate animal models of the disease can make a better understanding of the occurrence, development, patho-genesis,prevention and treatment of DPN. Therefore,a reasonable construction of animal models is related to the success of experimental research. Up to date, experimental animals used in the research of diabetic foot neuropathy include rats, nude mice,transgenic mice,and so on. Nerve injury models can be generated by different means,such as ischemia reper-fusion,resection or ligation of nerves and scalds. This article will review the recent research progress of diabetic foot neu-ropathy animal models.