Research progress of animal models of renal fibrosis and their characteristics / 中国实验动物学报
Acta Laboratorium Animalis Scientia Sinica
;
(6): 398-403, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-703241
ABSTRACT
Renal fibrosis is a common pathological pathway of chronic kidney diseases that leads to end-stage renal failure. The pathological changes include glomerulosclerosis and renal interstitial fibrosis. Ideal animal models for the study of pathologic mechanisms and drug development of chronic kidney disease are of great significance. At present, the method of establishment of animal models include drug or toxin induction, surgical models and gene knockout, etc. Different animal models have various characteristics of renal function and pathology, but can not completely simulate human chronic kidney disease, suggesting the complexity of chronic kidney diseases. So the preparation and research of the animal models is important for understanding the pathological mechanisms, prevention and treatment of renal fibrosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Acta Laboratorium Animalis Scientia Sinica
Ano de publicação:
2018
Tipo de documento:
Artigo
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